Discipline I · INSECAB Analytical Framework
Training in the design and statistical analysis of clinical studies. This is not about applying formulas: it is about learning to choose the analytical strategy that fits each research question and to document it rigorously.
One frequent error is not technical but strategic: defining the analysis method after the data have been collected, instead of planning it from the study design onwards. Clinical Biostatistics at INSECAB begins with the design, not with the spreadsheet.
Every analysis is documented reproducibly, with open, audited code, so that any co-author or reviewer can verify each methodological decision. That is what helps a manuscript arrive better prepared for the review process.
Principles of the INSECAB approach
Design first, analysis second
The statistical strategy is defined before any data are collected, not as a patch afterwards.
Reproducibility as the standard
Every analytical pipeline is documented in verifiable open code.
Clinical interpretation, not just p-values
Results are translated into the language of the real clinical decision.
Aligned with international guidelines
STROBE, CONSORT, TRIPOD and PRISMA built in from the start.
Areas of application
Observational studies, clinical trials and prospective cohorts. Defining the sample size, the outcome variables and the analytical strategy before a single data point is collected.
Logistic, linear and Poisson regression and mixed models. Internal validation with bootstrapping and cross-validation. Calibration and clinical interpretation of the results.
Kaplan–Meier, Cox models with the proportional hazards assumption, competing risks and time-dependent covariates. Reporting in line with international guidelines.
Building and validating clinical risk scores. Assessment of net benefit with DCA to determine whether a model adds real value to decision-making.
Reports generated with Quarto/R Markdown, aligned with STROBE, CONSORT and TRIPOD. Full documentation of the analytical pipeline to facilitate peer review.
Who it is for
In the INSECAB programme you will learn
Other disciplines in the INSECAB framework